Body Sculpting with Injection Lipolysis
Kybella® or Compounded PCDC may be right for you if:
- You are bothered (unhappy, self-conscious, embarrassed) by localized areas of fat accumulation
- You feel this condition makes you look older or heavier than you actually are
- You eat well and exercise, and perhaps even lose weight and inches, but the localized fatty area does not seem to go away
- You don’t want to have surgery or perhaps have had liposuction or laser or ultrasound fat reduction procedure and some irregularity remains
Kybella® from Allergan, the maker of Botox and the Juvéderm® family of fillers, now is available at the office as an FDA-approved therapy for submental fat. Use of this chemical might be considered in other body areas but then would be considered “off-label” use. However, additionally, a pharmaceutically-compounded and sterile formulation of phosphatidylcholine and deoxycholate (known as PPC/DC or PC/DC) is also available at the office for dissolving small areas of fat accumulation in other body areas though requires a specific patient prescription and compounding at out-of-town pharmacies and shipping to the office.
Injection lipolysis has become almost synonymous with the term “mesotherapy” but mesotherapy is a more general term, referring to technique of injection of substances under the skin where the depth of injection can vary depending upon which layer is being targeted for treatment and the solutions (vitamins, minerals, plant extracts, etc.) can vary depending upon the goals of therapy.
Injection lipolysis is specifically a cosmetic procedure in which chemicals or drugs (or mixtures there of) are injected under the skin into fatty areas with the goal of destroying fat cells. The practice evolved after investigators noted in 1960’s that intravenous infusion of phosphatidylcholine solutions could remove fat emboli, improve blood lipid levels and improve fatty liver cirrhosis. The brand Lipostabil (containing phosphatidylcholine and deoxycholate) was approved in Europe for these uses. It was later used off-label and was additionally demonstrated to be useful in reducing localized fat under the eyelid and in other body areas. Since then, other formulations of these chemical agents have been developed to use.
Injection lipolysis continues to be controversial, having proponents who seemed to find it useful and effective, as well as skeptics who have been concerned about inappropriate use, potential side effects, and, by the fact (in the US) that neither Lipostabil, nor other chemicals or drugs, have been FDA-approved for this use. However in 2016, Kybella® (Kythera outside the US), a form of deoxycholate, was FDA-approved specifically for dissolving submental fat or “double chin” though it is not approved for use elsewhere in the body as yet. But, your probably know that, various chemicals and drugs are used regularly by US medical providers and are often recommended by experts or specialty organizations for non-FDA-approved indications. For example, Botox® Cosmetic has been used for muscle relaxation to the upper forehead for years though has only recently gotten FDA-approval for use in that area of the face.
NOTE: These injections are NOT meant to be used for general weight loss, or for reduction of large or diffuse fat accumulations (which should be managed with dietary restriction and exercise) and since the injections are performed in incremental treatment stages to limit side effects and optimize aesthetic results, multiple treatments may be needed to achieve your aesthetic goals. Additionally the physician may deam some areas inappropriate for injection or some patients inappropriate candidates for these procedures.
See more information on the Allergan website about KYBELLA® .
NOTE: photo courtesy of jk1991 at FreeDigitalPhotos.net